|Other Names||Homeobox protein Hox-C11, Homeobox protein Hox-3H, HOXC11, HOX3H|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.|
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The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. HOXC11 binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development.
McIlroy, M., et al. Cancer Res. 70(4):1585-1594(2010)Zhang, X., et al. J. Cell. Mol. Med. 11(2):299-306(2007)Kosaki, K., et al. Teratology 65(2):50-62(2002)Mitchelmore, C., et al. J. Biol. Chem. 273(21):13297-13306(1998)
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