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HPN Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P05981
Peptide ID 91013128
Additional Information
Gene ID 3249
Other Names Serine protease hepsin, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPN
Synonyms TMPRSS1
Function Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Cellular Location Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein
Tissue Location Detected in liver and kidney.
Research Areas
Citations (0)

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Background

HPN is a type II transmembrane serine protease. This protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer.

References

Bethke, L., et al. J. Natl. Cancer Inst. 100(4):270-276(2008)Giglia-Mari, G., et al. Nat. Genet. 36(7):714-719(2004)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)

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$ 80.00
Cat# BP9511c
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