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HS3ST1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14792
Peptide ID 91013130
Additional Information
Gene ID 9957
Other Names Heparan sulfate glucosamine 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, 3-OST-1, Heparan sulfate 3-O-sulfotransferase 1, h3-OST-1, HS3ST1, 3OST, 3OST1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HS3ST1
Synonyms 3OST, 3OST1
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
Cellular Location Golgi apparatus lumen.
Tissue Location Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta
Research Areas
Citations (0)

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Background

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.

References

Edavettal, S.C., et al. Biochemistry 43(16):4680-4688(2004) Hernaiz, M., et al. Biochem. Biophys. Res. Commun. 276(1):292-297(2000) Liu, J., et al. J. Biol. Chem. 274(8):5185-5192(1999) Shworak, N.W., et al. J. Biol. Chem. 274(8):5170-5184(1999)

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$ 80.00
Cat# BP9512a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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