|Other Names||Heparan sulfate glucosamine 3-O-sulfotransferase 2, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, 3-OST-2, Heparan sulfate 3-O-sulfotransferase 2, h3-OST-2, HS3ST2, 3OST2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity.
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010) Nat. Genet. 41(7):824-828(2009) Mochizuki, H., et al. J. Biol. Chem. 283(45):31237-31245(2008) Lawrence, R., et al. Matrix Biol. 26(6):442-455(2007) O'Donnell, C.D., et al. Virology 346(2):452-459(2006) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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