HS3ST3A1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y663 |
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Gene ID | 9955 |
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Other Names | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, 3-OST-3A, Heparan sulfate 3-O-sulfotransferase 3A1, h3-OST-3A, HS3ST3A1, 3OST3A1, HS3ST3A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HS3ST3A1 |
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Synonyms | 3OST3A1, HS3ST3A |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768, PubMed:10608887, PubMed:15304505). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:9988768, PubMed:15304505). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide.
References
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) : Moon, A.F., et al. J. Biol. Chem. 279(43):45185-45193(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003) Salehi, L.B., et al. Hum. Genet. 111 (4-5), 401-404 (2002) : Liu, J., et al. J. Biol. Chem. 274(53):38155-38162(1999) Shukla, D., et al. Cell 99(1):13-22(1999)
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