|Other Names||Testosterone 17-beta-dehydrogenase 3, 17-beta-hydroxysteroid dehydrogenase type 3, 17-beta-HSD 3, Testicular 17-beta-hydroxysteroid dehydrogenase, HSD17B3, EDH17B3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.|
|Cellular Location||Endoplasmic reticulum|
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This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) : Sata, F., et al. J Sex Med (2010) In press : Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009) Chakrabarti, B., et al. Autism Res 2(3):157-177(2009) Beuten, J., et al. Cancer Epidemiol. Biomarkers Prev. 18(6):1869-1880(2009) Andersson, S., et al. J. Clin. Endocrinol. Metab. 81(1):130-136(1996)
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