|Other Names||Alpha-adducin, Erythrocyte adducin subunit alpha, ADD1, ADDA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit|
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Provided below are standard protocols that you may find useful for product applications.
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C.
Davila, S., et al. Genes Immun. (2010) In press : Paternoster, L., et al. Circ Cardiovasc Genet 3(1):15-21(2010) Ferrandi, M., et al. J. Mol. Med. 88(2):203-217(2010) Wang, R., et al. J. Appl. Genet. 51(1):87-94(2010) Niu, W.Q., et al. J Hum Hypertens (2009) In press : Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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