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EIF2A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BY44 |
|---|
| Gene ID | 83939 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 2A, eIF-2A, 65 kDa eukaryotic translation initiation factor 2A, Eukaryotic translation initiation factor 2A, N-terminally processed, EIF2A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EIF2A |
|---|---|
| Function | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. |
| Tissue Location | Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).
References
Willis, K.L., et al. Virology 394(1):73-81(2009) Spurgeon, M.E., et al. J. Virol. 83(19):9970-9982(2009) Lu, W., et al. J. Biol. Chem. 284(36):24281-24288(2009) Yang, J., et al. Mol. Cell. Biol. 29(8):2243-2253(2009) Schewe, D.M., et al. Cancer Res. 69(4):1545-1552(2009) Olsen, J.V., et al. Cell 127(3):635-648(2006)
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