|Other Names||Eukaryotic translation initiation factor 2A, eIF-2A, 65 kDa eukaryotic translation initiation factor 2A, Eukaryotic translation initiation factor 2A, N-terminally processed, EIF2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.|
|Tissue Location||Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta|
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Provided below are standard protocols that you may find useful for product applications.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).
Willis, K.L., et al. Virology 394(1):73-81(2009) Spurgeon, M.E., et al. J. Virol. 83(19):9970-9982(2009) Lu, W., et al. J. Biol. Chem. 284(36):24281-24288(2009) Yang, J., et al. Mol. Cell. Biol. 29(8):2243-2253(2009) Schewe, D.M., et al. Cancer Res. 69(4):1545-1552(2009) Olsen, J.V., et al. Cell 127(3):635-648(2006)
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