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HABP4 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5JVS0
Additional Information
Gene ID 22927
Other Names Intracellular hyaluronan-binding protein 4, IHABP-4, IHABP4, Ki-1/57 intracellular antigen, HABP4 (HGNC:17062)
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HABP4 (HGNC:17062)
Function Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:21771594, PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163}
Tissue Location Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes
Research Areas
Citations (0)
citation

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Background

May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

References

??ressan, G.C., et al. FEBS J. 276(14):3770-3783(2009)??ressan, G.C., et al. J. Proteome Res. 7(10):4465-4474(2008)??assos, D.O., et al. FEBS J. 273(17):3946-3961(2006)??ery, F.C., et al. Biochem. Biophys. Res. Commun. 341(3):847-855(2006)??telzl, U., et al. Cell 122(6):957-968(2005)??ery, F.C., et al. J. Biol. Chem. 279(12):11444-11455(2004)

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$ 277.78
Cat# BP9550b
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