SLC39A4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6P5W5 |
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Gene ID | 55630 |
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Other Names | Zinc transporter ZIP4, Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4, SLC39A4, ZIP4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC39A4 (HGNC:17129) |
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Synonyms | ZIP4 |
Function | Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:32348750, PubMed:17202136). Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589). |
Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Recycling endosome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Apical cell membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to Zn(2+) availability. Zn(2+) deficiency promotes accumulation of SLC39A4 on the surface membrane, whereas high extracellular Zn(2+) levels induce internalization of SLC39A4, but also trigger drastic removal of cellular SLC39A4 via proteasomal and lysosomal degradation pathways. {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:32348750} |
Tissue Location | Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC39A4 is a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein is required for zinc uptake in the intestine.
References
??i, M., et al. Clin. Cancer Res. 15(19):5993-6001(2009)??akano, H., et al. Br. J. Dermatol. 161(1):184-186(2009)??ardi, A., et al. Br. J. Dermatol. 160(6):1346-1348(2009)??chmitt, S., et al. Hum. Mutat. 30(6):926-933(2009)??averakis, E., et al. Dermatol. Online J. 13 (3), 11 (2007) :
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