|Other Names||Protein MAL2, MAL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non- polarized Hep-G2 cells, distributed to the perinuclear region|
|Tissue Location||Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
MAL2 is a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.
??ello-Morales, R., et al. Exp. Cell Res. 315(19):3453-3465(2009)??otkin, S.G., et al. PLoS ONE 4 (8), E6501 (2009) :??anayan, S., et al. BMC Cell Biol. 10, 7 (2009) :??ohan, S., et al. Clin. Cancer Res. 12(23):6937-6945(2006)??arbaric, D., et al. Leuk. Res. 30(11):1355-1363(2006)
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