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TNPO2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14787
Peptide ID 91102128
Additional Information
Gene ID 30000
Other Names Transportin-2, Karyopherin beta-2b, TNPO2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNPO2
Function Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)

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Background

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

References

??wing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :??ee, B.J., et al. Cell 126(3):543-558(2006)??uttinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 101(9):2918-2923(2004)??hamsher, M.K., et al. Proc. Natl. Acad. Sci. U.S.A. 99(22):14195-14199(2002)

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$ 80.00
Cat# BP9561b
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