|Other Names||Ellis-van Creveld syndrome protein, DWF-1, EVC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium Cell projection, cilium membrane. Note=EVC2 is required for the localization of EVC at the base of primary cilia|
|Tissue Location||Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung|
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Provided below are standard protocols that you may find useful for product applications.
EVC is a protein containing a leucine zipper and a transmembrane domain.
??alencia, M., et al. Hum. Mutat. 30(12):1667-1675(2009)??und, K.L., et al. Hum. Mol. Genet. 18(10):1813-1824(2009)??ust, A., et al. Neuromolecular Med. 11(1):13-19(2009)
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