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EVC Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P57679
Additional Information
Gene ID 2121
Other Names Ellis-van Creveld syndrome protein, DWF-1, EVC
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EVC
Function Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P57680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P57680}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P57680}. Cell projection, cilium {ECO:0000250|UniProtKB:P57680}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P57680}. Note=EVC2 is required for the localization of EVC at the base of primary cilia. The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:P57680}
Tissue Location Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung
Research Areas
Citations (0)
citation

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Background

EVC is a protein containing a leucine zipper and a transmembrane domain.

References

??alencia, M., et al. Hum. Mutat. 30(12):1667-1675(2009)??und, K.L., et al. Hum. Mol. Genet. 18(10):1813-1824(2009)??ust, A., et al. Neuromolecular Med. 11(1):13-19(2009)

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$ 277.78
Cat# BP9590a
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