|Other Names||AMP deaminase 1, AMP deaminase isoform M, Myoadenylate deaminase, AMPD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||AMP deaminase plays a critical role in energy metabolism.|
|Tissue Location||Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Hanisch, F., et al. J. Neurol. 255(3):318-322(2008)Vladutiu, G.D., et al. Muscle Nerve 34(2):153-162(2006)Mahnke-Zizelman, D.K., et al. J. Biol. Chem. 277(45):42654-42662(2002)
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