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MICAL2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O94851
Additional Information
Gene ID 9645
Other Names Protein-methionine sulfoxide oxidase MICAL2, 11413-, Molecule interacting with CasL protein 2, MICAL-2, MICAL2, KIAA0750, MICAL2PV1, MICAL2PV2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICAL2 (HGNC:24693)
Function Methionine monooxygenase that promotes depolymerization of F- actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF- A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}
Research Areas
Citations (0)
citation

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References

Ashida, S., et al. Clin. Cancer Res. 12(9):2767-2773(2006)Fischer, J., et al. Biochem. Biophys. Res. Commun. 328(2):415-423(2005)

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$ 277.78
Cat# BP9597a
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