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KIR2DS5 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14953
Additional Information
Gene ID 3810
Other Names Killer cell immunoglobulin-like receptor 2DS5, CD158 antigen-like family member G, MHC class I NK cell receptor, Natural killer-associated transcript 9, NKAT-9, CD158g, KIR2DS5, CD158G, NKAT9
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIR2DS5
Synonyms CD158G, NKAT9
Function Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).
Cellular Location Cell membrane; Single- pass type I membrane protein; Extracellular side
Tissue Location Expressed on a discrete subset of peripheral blood NK cells.
Research Areas
Citations (0)

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Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

References

Vilches, C., et al. Tissue Antigens 56(5):453-456(2000)Bottino, C., et al. Eur. J. Immunol. 26(8):1816-1824(1996)Dohring, C., et al. Immunogenetics 44(3):227-230(1996)Wagtmann, N., et al. Immunity 2(5):439-449(1995)

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$ 80.00
Cat# BP9602c
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