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CPSF4 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95639
Peptide ID 90921026
Additional Information
Gene ID 10898
Other Names Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, Neb-1, No arches homolog, CPSF4, CPSF30, NAR, NEB1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPSF4
Synonyms CPSF30, NAR, NEB1
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.


Twu, K.Y., et al. J. Virol. 81(15):8112-8121(2007)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Kaufmann, I., et al. EMBO J. 23(3):616-626(2004)de Vries, H., et al. EMBO J. 19(21):5895-5904(2000)

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$ 80.00
Cat# BP9617c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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