|Other Names||Centromere protein I, CENP-I, FSH primary response protein 1, Follicle-stimulating hormone primary response protein, Interphase centromere complex protein 19, Leucine-rich primary response protein 1, CENPI, FSHPRH1, ICEN19, LRPR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FSHPRH1, ICEN19, LRPR1|
|Function||Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.|
|Cellular Location||Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex|
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Provided below are standard protocols that you may find useful for product applications.
CENPI is involved in the response of gonadal tissues to follicle-stimulating hormone.
Cheeseman, I.M., et al. Mol. Biol. Cell 19(2):587-594(2008)Izuta, H., et al. Genes Cells 11(6):673-684(2006)Okada, M., et al. Nat. Cell Biol. 8(5):446-457(2006)
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