|Other Names||Heat shock protein beta-6, HspB6, Heat shock 20 kDa-like protein p20, HSPB6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Translocates to nuclear foci during heat shock.|
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Provided below are standard protocols that you may find useful for product applications.
HSPB6 is associated with actin (see MIM 102540) and modulates smooth muscle relaxation (Tessier et al., 2003 [PubMed 12842460]).
Fuchs, M., et al. Biochem. J. 425(1):245-255(2010)Qian, J., et al. Circ. Res. 105(12):1223-1231(2009)Bagneris, C., et al. J. Mol. Biol. 392(5):1242-1252(2009)
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