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FAM175A Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UWZ7
Peptide ID 91102016
Additional Information
Gene ID 84142
Other Names BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A, FAM175A, ABRA1, CCDC98
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAM175A
Synonyms ABRA1, CCDC98
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Cellular Location Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Research Areas
Citations (0)

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Background

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

References

Wang, B., et al. Genes Dev. 23(6):729-739(2009)Feng, L., et al. Genes Dev. 23(6):719-728(2009)Shao, G., et al. Genes Dev. 23(6):740-754(2009)

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$ 80.00
Cat# BP9636c
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