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IWS1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96ST2
Peptide ID 91102029
Additional Information
Gene ID 55677
Other Names Protein IWS1 homolog, IWS1-like protein, IWS1, IWS1L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IWS1
Synonyms IWS1L
Function Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00649, ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882}
Research Areas
Citations (0)

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Yoh, S.M., et al. Genes Dev. 22(24):3422-3434(2008)Liu, Z., et al. Biochem. Biophys. Res. Commun. 353(1):47-53(2007)Yoh, S.M., et al. Genes Dev. 21(2):160-174(2007)

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$ 80.00
Cat# BP9638b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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