|Other Names||Lactosylceramide 1, 3-N-acetyl-beta-D-glucosaminyltransferase, Lactotriaosylceramide synthase, Lc(3)Cer synthase, Lc3 synthase, UDP-GlcNAc:beta-Gal beta-1, 3-N-acetylglucosaminyltransferase 5, BGnT-5, Beta-1, 3-Gn-T5, Beta-1, 3-N-acetylglucosaminyltransferase 5, Beta3Gn-T5, B3GNT5|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus|
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B3GNT5 is a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids.
Marcos, N.T., et al. J. Clin. Invest. 118(6):2325-2336(2008)Togayachi, A., et al. J. Biol. Chem. 276(25):22032-22040(2001)
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