|Other Names||All-trans retinoic acid-induced differentiation factor, Apoptosis-related protein 3, APR-3, p18, ATRAID, APR3, C2orf28|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.|
|Cellular Location||Nucleus envelope. Cell membrane; Single-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284)|
|Tissue Location||Weakly expressed in hematopoietic cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
APR3 may play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.
Yu, F., et al. Biochem. Biophys. Res. Commun. 358(4):1041-1046(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Zhu, F., et al. BioTechniques 29(2):310-313(2000)
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