APR3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6UW56 |
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Gene ID | 51374 |
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Other Names | All-trans retinoic acid-induced differentiation factor, Apoptosis-related protein 3, APR-3, p18, ATRAID, APR3, C2orf28 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ATRAID (HGNC:24090) |
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Synonyms | APR3, C2orf28 |
Function | Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). |
Cellular Location | Nucleus envelope. Cell membrane; Single-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284) |
Tissue Location | Weakly expressed in hematopoietic cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
APR3 may play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.
References
Yu, F., et al. Biochem. Biophys. Res. Commun. 358(4):1041-1046(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Zhu, F., et al. BioTechniques 29(2):310-313(2000)
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