|Other Names||Tubulin-specific chaperone E, Tubulin-folding cofactor E, TBCE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
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Provided below are standard protocols that you may find useful for product applications.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010) Padidela, R., et al. J. Clin. Endocrinol. Metab. 94(8):2686-2691(2009) Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009) Jin, S., et al. Development 136(9):1571-1581(2009) Diaz, G.A., et al. Genomics 54(1):13-18(1998) Parvari, R., et al. Am. J. Hum. Genet. 63(1):163-169(1998)
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