|Other Names||Carboxylesterase 3, Liver carboxylesterase 31 homolog, CES3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Expressed in liver, colon and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system.
Sanghani, S.P., et al. Protein Pept. Lett. 16(10):1207-1214(2009) Fukami, T., et al. Pharmacogenet. Genomics 18(10):911-920(2008) Sanghani, S.P., et al. Drug Metab. Dispos. 32(5):505-511(2004) Sanghani, S.P., et al. Clin. Cancer Res. 9(13):4983-4991(2003)
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