|Other Names||Protein O-glucosyltransferase 1, 241-, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase, POGLUT1, C3orf9, CLP46, KTELC1, MDSRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C3orf9, CLP46, KTELC1, MDSRP|
|Function||Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Karadonta, A.V., et al. Int J Immunopathol Pharmacol 22(3):787-793(2009)Teng, Y., et al. Gene 371(1):7-15(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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