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GNB5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14775
Peptide ID 91013033
Additional Information
Gene ID 10681
Other Names Guanine nucleotide-binding protein subunit beta-5, Gbeta5, Transducin beta chain 5, GNB5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNB5
Function Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Cellular Location Membrane {ECO:0000250|UniProtKB:P62881}.
Tissue Location Expressed in multiple tissues.
Research Areas
Citations (0)

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Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

References

# Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)# Howlett, A.C., et al. J. Biol. Chem. 284(24):16386-16399(2009)# Rao, A., et al. J. Neurosci. 27(51):14199-14204(2007)# Drenan, R.M., et al. J. Biol. Chem. 281(38):28222-28231(2006)# Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 80.00
Cat# BP9687a
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