|Other Names||Calpain-5, 3422-, Calpain htra-3, New calpain 3, nCL-3, CAPN5, NCL3|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer|
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Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Penna, I., et al. Mol. Hum. Reprod. 14(10):613-618(2008)
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