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NEIL1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96FI4
Peptide ID 80917091
Additional Information
Gene ID 79661
Other Names Endonuclease 8-like 1, 322-, DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, NEH1, Nei-like protein 1, NEIL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEIL1
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).


Zhao, X., et al. Biochemistry 49(8):1658-1666(2010)Forsbring, M., et al. Carcinogenesis 30(7):1147-1154(2009)Couve, S., et al. J. Biol. Chem. 284(18):11963-11970(2009)Muftuoglu, M., et al. J. Biol. Chem. 284(14):9270-9279(2009)Horikawa, Y., et al. Clin. Cancer Res. 14(23):7956-7962(2008)

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$ 80.00
Cat# BP9696c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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