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HFE2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6ZVN8
Additional Information
Gene ID 148738
Other Names Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HJV (HGNC:4887)
Synonyms HFE2, RGMC
Function Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966).
Cellular Location Cell membrane; Lipid-anchor, GPI- anchor. Note=Also released in the extracellular space
Tissue Location Adult and fetal liver, heart, and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.

References

Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)

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$ 277.78
Cat# BP9699c
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