INSC Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q1MX18 |
---|---|
Other Accession | NP_001027024.3, NP_001036001.1 |
Clone Names | 100111272 |
Gene ID | 387755 |
---|---|
Other Names | Protein inscuteable homolog, INSC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | INSC |
---|---|
Function | May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, cell cortex. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles |
Tissue Location | Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
In Drosophila, neuroblasts divide asymmetrically intoanother neuroblast at the apical side and a smaller ganglion mothercell on the basal side. Cell polarization is precisely regulated by2 apically localized multiprotein signaling complexes that aretethered by Inscuteable, which regulates their apical localization(Izaki et al., 2006 [PubMed 16458856]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)Rivadeneira, F., et al. Nat. Genet. 41(11):1199-1206(2009)Izaki, T., et al. Biochem. Biophys. Res. Commun. 341(4):1001-1006(2006)Katoh, M., et al. Int. J. Mol. Med. 11(1):111-116(2003)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.