|Other Names||Dynactin subunit 1, 150 kDa dynein-associated polypeptide, DAP-150, DP-150, p135, p150-glued, DCTN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Colocalizes with microtubules|
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Provided below are standard protocols that you may find useful for product applications.
DCTN1 is the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.
Hong, Z., et al. Cell Res. 19(12):1334-1349(2009)Zhapparova, O.N., et al. Traffic 10(11):1635-1646(2009)Rocha, N., et al. J. Cell Biol. 185(7):1209-1225(2009)Vilarino-Guell, C., et al. Neurology 72(23):2024-2028(2009)Chan, Y.W., et al. J. Cell Biol. 185(5):859-874(2009)
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