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ZDHHC9 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y397 |
|---|
| Gene ID | 51114 |
|---|---|
| Other Names | Palmitoyltransferase ZDHHC9, Zinc finger DHHC domain-containing protein 9, DHHC-9, DHHC9, Zinc finger protein 379, Zinc finger protein 380, ZDHHC9, CXorf11, ZDHHC10, ZNF379, ZNF380 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC9 {ECO:0000303|PubMed:37802025, ECO:0000312|HGNC:HGNC:18475} |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, HRAS, NRAS and CGAS (PubMed:16000296, PubMed:27481942, PubMed:37802025). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (PubMed:16000296). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein- coupled receptor signaling (PubMed:27481942). Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed:37802025). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
References
Mansilla, F., et al. Br. J. Cancer 96(12):1896-1903(2007)Raymond, F.L., et al. Am. J. Hum. Genet. 80(5):982-987(2007)Zhou, F.L., et al. Cancer Immunol. Immunother. 55(8):910-917(2006)
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