|Other Names||IST1 homolog, hIST1, Putative MAPK-activating protein PM28, IST1, KIAA0174|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.|
|Cellular Location||Cytoplasmic vesicle Note=Localizes to the midbody of dividing cells|
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KIAA0174 is proposed to be involved in specific functions of the ESCRT machinery. It is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvment in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
Bajorek, M., et al. Nat. Struct. Mol. Biol. 16(7):754-762(2009)Agromayor, M., et al. Mol. Biol. Cell 20(5):1374-1387(2009)ajorek, M., et al. Mol. Biol. Cell 20(5):1360-1373(2009)
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