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KIAA0174 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P53990
Peptide ID 91102122
Additional Information
Gene ID 9798
Other Names IST1 homolog, hIST1, Putative MAPK-activating protein PM28, IST1, KIAA0174
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IST1
Synonyms KIAA0174
Function ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Cellular Location Cytoplasmic vesicle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPG20 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712)
Research Areas
Citations (0)

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Background

KIAA0174 is proposed to be involved in specific functions of the ESCRT machinery. It is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvment in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.

References

Bajorek, M., et al. Nat. Struct. Mol. Biol. 16(7):754-762(2009)Agromayor, M., et al. Mol. Biol. Cell 20(5):1374-1387(2009)ajorek, M., et al. Mol. Biol. Cell 20(5):1360-1373(2009)

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$ 80.00
Cat# BP9721a
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