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ANKH Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HCJ1 |
|---|
| Gene ID | 56172 |
|---|---|
| Other Names | Progressive ankylosis protein homolog, ANK, ANKH, KIAA1581 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANKH {ECO:0000303|PubMed:35147247, ECO:0000312|HGNC:HGNC:15492} |
|---|---|
| Function | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1 (PubMed:32639996, PubMed:35147247, PubMed:20943778). Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength (PubMed:32639996). The transport mechanism remains to be elucidated (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Found in osteoblasts from mandibular bone and from iliac bone; not detected in osteoclastic cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
References
Wang, J., et al. J. Rheumatol. 36(6):1265-1272(2009)Ho, A.M., et al. Science 289(5477):265-270(2000)Rojas, K., et al. Genomics 62(2):177-183(1999)
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