|Other Names||Progressive ankylosis protein homolog, ANK, ANKH, KIAA1581|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Found in osteoblasts from mandibular bone and from iliac bone; not detected in osteoclastic cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
Wang, J., et al. J. Rheumatol. 36(6):1265-1272(2009)Ho, A.M., et al. Science 289(5477):265-270(2000)Rojas, K., et al. Genomics 62(2):177-183(1999)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.