|Other Names||Progressive ankylosis protein homolog, ANK, ANKH, KIAA1581|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Found in osteoblasts from mandibular bone and from iliac bone; not detected in osteoclastic cells|
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Provided below are standard protocols that you may find useful for product applications.
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
Wang, J., et al. J. Rheumatol. 36(6):1265-1272(2009)Ho, A.M., et al. Science 289(5477):265-270(2000)Rojas, K., et al. Genomics 62(2):177-183(1999)
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