|Other Names||Rab11 family-interacting protein 4, FIP4-Rab11, Rab11-FIP4, Arfophilin-2, RAB11FIP4, ARFO2, KIAA1821|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.|
|Cellular Location||Endosome. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein Cleavage furrow. Midbody Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis|
|Tissue Location||Present at high level in testis (at protein level). Weakly expressed in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).
Douglas, J., et al. Nat. Genet. 39(8):963-965(2007)Shiba, T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(42):15416-15421(2006)Lim, J., et al. Cell 125(4):801-814(2006)Fielding, A.B., et al. EMBO J. 24(19):3389-3399(2005)Wilson, G.M., et al. Mol. Biol. Cell 16(2):849-860(2005)
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