|Other Names||Nitric oxide synthase, brain, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS, NOS1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).|
|Tissue Location||Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. This gene encodes a nitric oxide synthase which is highly expressed in skeletal muscle.
Laas, K., et al. Psychopharmacology (Berl.) 209(3):255-261(2010)Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)Retz, W., et al. J Neural Transm 117(3):321-324(2010)Guan, Z.W., et al. J. Biol. Chem. 285(5):3064-3075(2010)Okumura, T., et al. Neuropsychobiology 61(2):57-63(2010)Song, T., et al. FEBS Lett. 570 (1-3), 133-137 (2004) Watanabe, Y., et al. Biochem. J. 372 (PT 2), 465-471 (2003) Chen, Z.P., et al. Am. J. Physiol. Endocrinol. Metab. 279 (5), E1202-E1206 (2000)
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