|Other Names||ATP-dependent RNA helicase SUPV3L1, mitochondrial, Suppressor of var1 3-like protein 1, SUV3-like protein 1, SUPV3L1, SUV3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.|
|Cellular Location||Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid|
|Tissue Location||Broadly expressed.|
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SUV3L1 is an ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. It may protect cells from apoptosis.
Szczesny, R.J., et al. Nucleic Acids Res. 38(1):279-298(2010)Wang, D.D., et al. J. Biol. Chem. 284(31):20812-20821(2009)Khidr, L., et al. J. Biol. Chem. 283(40):27064-27073(2008)Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)Pereira, M., et al. Mech. Ageing Dev. 128 (11-12), 609-617 (2007) Shu, Z., et al. Biochemistry 43(16):4781-4790(2004)
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