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GEFT Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86VW2
Peptide ID 91013007
Additional Information
Gene ID 115557
Other Names Rho guanine nucleotide exchange factor 25, Guanine nucleotide exchange factor GEFT, Rac/Cdc42/Rho exchange factor GEFT, RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT, p63RhoGEF, ARHGEF25, GEFT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GEFT
Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).
Cellular Location Cell membrane. Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions
Tissue Location Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
Research Areas
Citations (0)

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The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange.


Shankaranarayanan, A., et al. J. Biol. Chem. 283(50):34923-34934(2008)Swenson-Fields, K.I., et al. Mol. Cell 32(1):43-56(2008)Lutz, S., et al. Science 318(5858):1923-1927(2007)Bryan, B.A., et al. J. Neurosci. Res. 83(7):1151-1159(2006)Lutz, S., et al. J. Biol. Chem. 280(12):11134-11139(2005)

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$ 80.00
Cat# BP9782c
Availability: In Stock
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