|Other Names||Rho guanine nucleotide exchange factor 25, Guanine nucleotide exchange factor GEFT, Rac/Cdc42/Rho exchange factor GEFT, RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT, p63RhoGEF, ARHGEF25, GEFT|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).|
|Cellular Location||Cell membrane. Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions|
|Tissue Location||Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.|
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Provided below are standard protocols that you may find useful for product applications.
The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange.
Shankaranarayanan, A., et al. J. Biol. Chem. 283(50):34923-34934(2008)Swenson-Fields, K.I., et al. Mol. Cell 32(1):43-56(2008)Lutz, S., et al. Science 318(5858):1923-1927(2007)Bryan, B.A., et al. J. Neurosci. Res. 83(7):1151-1159(2006)Lutz, S., et al. J. Biol. Chem. 280(12):11134-11139(2005)
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