|Other Names||Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Sperm antigen 36, SA-36, GPI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.|
|Cellular Location||Cytoplasm. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
Shih, W.L., et al. Cancer Lett. 290(2):223-237(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Araki, K., et al. J. Biol. Chem. 284(47):32305-32311(2009)Tsutsumi, S., et al. Int. J. Oncol. 35(5):1117-1121(2009)Funasaka, T., et al. Cancer Res. 69(13):5349-5356(2009)Yanagawa, T., et al. J. Biol. Chem. 280(11):10419-10426(2005)Haga, A., et al. Biochim. Biophys. Acta 1480 (1-2), 235-244 (2000)
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