|Other Names||Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain|
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Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Chao, C., et al. J. Surg. Res. 156(1):26-31(2009)Ananias, H.J., et al. Prostate 69(10):1101-1108(2009)Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009)
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