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SGMS2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8NHU3
Peptide ID 90904163
Additional Information
Gene ID 166929
Other Names Phosphatidylcholine:ceramide cholinephosphotransferase 2, Sphingomyelin synthase 2, SGMS2, SMS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGMS2
Synonyms SMS2
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.
Cellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase
Tissue Location Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells.
Research Areas
Citations (0)

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Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene.


Ternes, P., et al. J. Lipid Res. 50(11):2270-2277(2009)Liu, J., et al. Arterioscler. Thromb. Vasc. Biol. 29(6):850-856(2009)Tani, M., et al. Biochem. Biophys. Res. Commun. 381(3):328-332(2009)Wang, W., et al. Plant Cell 20(11):3163-3179(2008)Yeang, C., et al. Biochim. Biophys. Acta 1781(10):610-617(2008)Villani, M., et al. Biochem. J. 414(1):31-41(2008)

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$ 80.00
Cat# BP9801b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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