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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TM173 Antibody (C-term) Blocking Peptide   

TM173 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86WV6
Peptide ID 91113029
Additional Information
Gene ID 340061
Other Names Stimulator of interferon genes protein, hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173, TMEM173, ERIS, MITA, STING
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM173
Function Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cytoplasm Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited
Tissue Location Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
Research Areas
Citations (0)

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Sun, W., et al. Proc. Natl. Acad. Sci. U.S.A. 106(21):8653-8658(2009)Zhong, B., et al. Immunity 30(3):397-407(2009)Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) Zhong, B., et al. Immunity 29(4):538-550(2008)Ishikawa, H., et al. Nature 455(7213):674-678(2008)Jin, L., et al. Mol. Cell. Biol. 28(16):5014-5026(2008)

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$ 80.00
Cat# BP9807b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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