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PRUNE Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86TP1
Peptide ID 91113034
Additional Information
Gene ID 58497
Other Names Protein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRUNE
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Cellular Location Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed
Tissue Location Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas
Research Areas
Citations (0)

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Background

PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.

References

Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)Middelhaufe, S., et al. Biochem. J. 407(2):199-205(2007)Kobayashi, T., et al. Mol. Cell. Biol. 26(3):898-911(2006)Zollo, M., et al. Clin. Cancer Res. 11(1):199-205(2005)Forus, A., et al. Oncogene 20(47):6881-6890(2001)

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$ 80.00
Cat# BP9809b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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