|Other Names||Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, 3424-, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM, ADAM19, MLTNB|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in many normal organ tissues and several cancer cell lines|
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction.
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)Styrkarsdottir, U., et al. Nat. Genet. 41(1):15-17(2009)Chan, M.W., et al. Neoplasia 10(9):908-919(2008)Tanabe, C., et al. Biochem. Biophys. Res. Commun. 352(1):111-117(2007)Melenhorst, W.B., et al. Am. J. Transplant. 6(7):1673-1681(2006)Kang, T., et al. J. Biol. Chem. 277(28):25583-25591(2002)
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