|Other Names||Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CANP3, CANPL3, NCL1|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Isoform I is skeletal muscle specific.|
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Provided below are standard protocols that you may find useful for product applications.
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.
Charlton, R., et al. Neuromuscul. Disord. 19(7):449-457(2009)Moretti, D., et al. Carcinogenesis 30(6):960-967(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)Beckmann, J.S., et al. Neuromuscul. Disord. 18(12):913-921(2008)Shirafuji, T., et al. Rinsho Shinkeigaku 48(9):651-655(2008)Diaz, B.G., et al. J. Biol. Chem. 279(26):27656-27666(2004)
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