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ZRANB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UGI0
Peptide ID 90909114
Additional Information
Gene ID 54764
Other Names Ubiquitin thioesterase ZRANB1, TRAF-binding domain-containing protein, hTrabid, Zinc finger Ran-binding domain-containing protein 1, ZRANB1, TRABID
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZRANB1
Synonyms TRABID
Function Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
Cellular Location Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.

References

Tran, H., et al. Genes Dev. 22(4):528-542(2008)Evans, P.C., et al. Biochem. J. 357 (PT 3), 617-623 (2001)

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$ 80.00
Cat# BP9830b
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