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IYD Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6PHW0 |
|---|
| Gene ID | 389434 |
|---|---|
| Other Names | Iodotyrosine dehalogenase 1, IYD-1, IYD, C6orf71, DEHAL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IYD {ECO:0000303|PubMed:25395621} |
|---|---|
| Function | Catalyzes the dehalogenation of halotyrosines such as 3- bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5- diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone- producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438). |
| Cellular Location | Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane |
| Tissue Location | Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.
References
Thomas, S.R., et al. J. Biol. Chem. 284(29):19659-19667(2009)Otowa, T., et al. J. Hum. Genet. 54(2):122-126(2009)Afink, G., et al. J. Clin. Endocrinol. Metab. 93(12):4894-4901(2008)Moreno, J.C., et al. N. Engl. J. Med. 358(17):1811-1818(2008)Krause, K., et al. Eur. J. Endocrinol. 156(3):295-301(2007)
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