|Other Names||Endoplasmic reticulum resident protein 44, ER protein 44, ERp44, Thioredoxin domain-containing protein 4, ERP44, KIAA0573, TXNDC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.|
|Cellular Location||Endoplasmic reticulum lumen|
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Provided below are standard protocols that you may find useful for product applications.
Fraldi, A., et al. Hum. Mol. Genet. 17(17):2610-2621(2008)Wang, L., et al. EMBO Rep. 9(7):642-647(2008)Mariappan, M., et al. J. Biol. Chem. 283(10):6375-6383(2008)Anelli, T., et al. EMBO J. 26(19):4177-4188(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
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