|Other Names||Protein C-ets-2, ETS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.|
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Provided below are standard protocols that you may find useful for product applications.
ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
Zabuawala, T., et al. Cancer Res. 70(4):1323-1333(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Shalaby, A.A., et al. Mod. Pathol. 22(8):996-1005(2009)Sutter, W., et al. J Craniomaxillofac Surg 37(5):263-271(2009)Staun-Ram, E., et al. Reprod. Biol. Endocrinol. 7, 135 (2009)
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